The correlation between obesity and the serum insulin level were studied in 10 healthy-adults, 18 non-diabetic patients without edema and 25 diabetic patients. Among all 53 cases,. there were 19 cases of obesity by Suh´s criteria of Korean ideal body weight (more than 2016 of ideal weight). The serum insulin and blood glucose at fasting and during 1008 oral glucose tolerance test were measured. Serum insulin was measured by method of Solid phase 1261 Radioimmunoassay (Coat-A-Count Insulin Kit).
The results were as follows:
1. In healthy adult, the level of fasting serum insulin was average 3. 1U/ml in non-obese,. 16.5U/ml in obese adults, The insulin level in 30 minutes after GTT, was 45.8U/ml in non-obese and 145. 5U/ml in obese adults. These data showed that hyperinsulinemia occurs in non-diabetic obesity either in fasting or after the glucose loading.
2. In nondiabetic patients without edema, the serum insulin levels were average 20.3U/ml in fasting, 61.4U/ml after 30 minutes, 100. 7U/ml after 60 minutes, 118. 7U/ml after 120 minutes and 52. 8U/ml after 180 minutes in non-obese patients. In obese patients, the serum insulin level were average 30.9U/ml, 109.OpU/ml after 30 minutes, 119.3U/ml after 60 minutes, 146.3U/ml after 120 minutes and 82.5U/ml after 180 minutes. These data showed the serum insulin level increased clearly but delayed than normal adult in obese patients.
3. The correlation between obesity index (body wt/ideal body wt) and fasting serum insulin level were studied. The coefficient of correlation was 0.88 in healthy adults and 0. 69 in non-obese patients. These data showed that serum insulin level is not only related to obesity but also body weight.
4. In diabetic patients, the fasting serum insulin level was as same as non-diabetic healthy adult or patient. There was no difference of serum insulin between obese and non-obese diabetic patients. It appeared slightly higher increase of serum insulin by GTT in obese
than non-obese diabetic patients but there was no statistical significance in t11e difference. There was no correlation between serum insulin level and obesity index (coefficient of correlation 0. 3) in diabetic patients.
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